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==E. coli PBP1b in complex with acyl-cephalexin and moenomycin==
==E. coli PBP1b in complex with acyl-cephalexin and moenomycin==
<StructureSection load='5hla' size='340' side='right' caption='[[5hla]], [[Resolution|resolution]] 2.36&Aring;' scene=''>
<StructureSection load='5hla' size='340' side='right'caption='[[5hla]], [[Resolution|resolution]] 2.36&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5hla]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HLA FirstGlance]. <br>
<table><tr><td colspan='2'>[[5hla]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HLA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63U:(2S)-2-[(1R)-1-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}-2-OXOETHYL]-5-METHYL-3,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>63U</scene>, <scene name='pdbligand=M0E:MOENOMYCIN'>M0E</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.36&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hl9|5hl9]], [[5hlb|5hlb]], [[5hld|5hld]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=63U:(2S)-2-[(1R)-1-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}-2-OXOETHYL]-5-METHYL-3,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC+ACID'>63U</scene>, <scene name='pdbligand=M0E:MOENOMYCIN'>M0E</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hla OCA], [http://pdbe.org/5hla PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hla RCSB], [http://www.ebi.ac.uk/pdbsum/5hla PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hla ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hla OCA], [https://pdbe.org/5hla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hla RCSB], [https://www.ebi.ac.uk/pdbsum/5hla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hla ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PBPB_ECOLI PBPB_ECOLI]] Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).  
[https://www.uniprot.org/uniprot/PBPB_ECOLI PBPB_ECOLI] Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5hla" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5hla" style="background-color:#fffaf0;"></div>
==See Also==
*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: King, D T]]
[[Category: Escherichia coli K-12]]
[[Category: Strynadka, N C.J]]
[[Category: Large Structures]]
[[Category: Inhibitor complex]]
[[Category: King DT]]
[[Category: Penicillin-binding protein]]
[[Category: Strynadka NCJ]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Transglycosylase]]
[[Category: Transpeptidase]]
Retrieved from "https://proteopedia.org/5hla"