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==Complex structure of human IL2 mutant, Proleukin, with Fab fragment of NARA1 antibody==
==Complex structure of human IL2 mutant, Proleukin, with Fab fragment of NARA1 antibody==
<StructureSection load='5lqb' size='340' side='right' caption='[[5lqb]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='5lqb' size='340' side='right'caption='[[5lqb]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5lqb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LQB FirstGlance]. <br>
<table><tr><td colspan='2'>[[5lqb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LQB FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lqb OCA], [http://pdbe.org/5lqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lqb RCSB], [http://www.ebi.ac.uk/pdbsum/5lqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lqb ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lqb OCA], [https://pdbe.org/5lqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lqb RCSB], [https://www.ebi.ac.uk/pdbsum/5lqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lqb ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.  
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.  
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5lqb" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5lqb" style="background-color:#fffaf0;"></div>
==See Also==
*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Wirth, E]]
[[Category: Wirth E]]
[[Category: Zou, C]]
[[Category: Zou C]]
[[Category: Anti-il2]]
[[Category: Cytokine]]
[[Category: Il2]]
[[Category: Nara1]]
[[Category: Proleukin]]
Retrieved from "https://proteopedia.org/5lqb"