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==Structure of human aldosterone synthase, CYP11B2, in complex with fadrozole==
==Structure of human aldosterone synthase, CYP11B2, in complex with fadrozole==
<StructureSection load='4fdh' size='340' side='right' caption='[[4fdh]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
<StructureSection load='4fdh' size='340' side='right'caption='[[4fdh]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4fdh]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FDH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FDH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4fdh]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FDH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0T3:4-[(5R)-5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL]BENZONITRILE'>0T3</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dvq|4dvq]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0T3:4-[(5R)-5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-5-YL]BENZONITRILE'>0T3</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Aldosterone synthase, CYP11B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fdh OCA], [https://pdbe.org/4fdh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fdh RCSB], [https://www.ebi.ac.uk/pdbsum/4fdh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fdh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fdh OCA], [http://pdbe.org/4fdh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fdh RCSB], [http://www.ebi.ac.uk/pdbsum/4fdh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fdh ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/C11B2_HUMAN C11B2_HUMAN]] Familial hyperreninemic hypoaldosteronism type 1;Familial hyperaldosteronism type I. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. The molecular defect causing hyperaldosteronism familial 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2.  
[https://www.uniprot.org/uniprot/C11B2_HUMAN C11B2_HUMAN] Familial hyperreninemic hypoaldosteronism type 1;Familial hyperaldosteronism type I. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. The molecular defect causing hyperaldosteronism familial 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/C11B2_HUMAN C11B2_HUMAN]] Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.<ref>PMID:23322723</ref>
[https://www.uniprot.org/uniprot/C11B2_HUMAN C11B2_HUMAN] Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.<ref>PMID:23322723</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Cytochrome P450|Cytochrome P450]]
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C]]
[[Category: Large Structures]]
[[Category: Edwards, A]]
[[Category: Arrowsmith C]]
[[Category: Park, H W]]
[[Category: Edwards A]]
[[Category: Shen, L]]
[[Category: Park H-W]]
[[Category: Strushkevich, N]]
[[Category: Shen L]]
[[Category: Tempel, W]]
[[Category: Strushkevich N]]
[[Category: Usanov, S A]]
[[Category: Tempel W]]
[[Category: Aldosterone synthase]]
[[Category: Usanov SA]]
[[Category: Cyp11b2]]
[[Category: Cytochrome p450]]
[[Category: Heme protein]]
[[Category: Inhibitor]]
[[Category: Membrane]]
[[Category: Mineralocorticoid]]
[[Category: Mitochondria]]
[[Category: Monooxygenase]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
Retrieved from "https://proteopedia.org/4fdh"