Borealin: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='350' side='right' caption='Human borealin N-terminal (green) complex with survivin (deepskyblue), INCENP N-terminal (pink), MES and Zn+2 ion (grey) (PDB code [[2qfa]])' scene='74/748865/Cv/1'> | ||
== Function == | == Function == | ||
Borealin (BOR) is a member of the chromosomal passenger complex (CPC) which includes [[survivin]] and INCENP. It is required for the stability of the bipolar mitotic spindle<ref>PMID:15249581</ref>. | Borealin (BOR) is a member of the chromosomal passenger complex (CPC) which includes [[survivin]] and [[INCENP]]. It is required for the stability of the bipolar mitotic spindle<ref>PMID:15249581</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
The interactions between BOR, survivin and INCENP involve a set of hydrophobic interactions formed by the three-helix bundle and links by electrostatic interactions<ref>PMID:17956729</ref>. | The interactions between BOR, survivin and INCENP involve a set of hydrophobic interactions formed by the three-helix bundle and links by <scene name='74/748865/Cv/2'>electrostatic interactions</scene><ref>PMID:17956729</ref>. | ||
</StructureSection> | </StructureSection> | ||
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[[2raw]], [[2rax]] – hBOR N-terminal + survivin – human<br /> | [[2raw]], [[2rax]] – hBOR N-terminal + survivin – human<br /> | ||
[[2qfa]] – hBOR N-terminal + survivin + INCENP<br /> | [[2qfa]], [[6yie]] – hBOR N-terminal + survivin + INCENP<br /> | ||
[[6yif]], [[6yih]] – hBOR N-terminal + survivin + INCENP + histone peptide<br /> | |||
[[2kdd]] – hBOR C-terminal – NMR<br /> | [[2kdd]] – hBOR C-terminal – NMR<br /> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
