4yvx: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of AKR1C3 complexed with glimepiride== | ==Crystal structure of AKR1C3 complexed with glimepiride== | ||
<StructureSection load='4yvx' size='340' side='right' caption='[[4yvx]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='4yvx' size='340' side='right'caption='[[4yvx]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4yvx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVX OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4yvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YVX FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GMR:3-ETHYL-4-METHYL-N-[2-(4-{[(CIS-4-METHYLCYCLOHEXYL)CARBAMOYL]SULFAMOYL}PHENYL)ETHYL]-2-OXO-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE'>GMR</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GMR:3-ETHYL-4-METHYL-N-[2-(4-{[(CIS-4-METHYLCYCLOHEXYL)CARBAMOYL]SULFAMOYL}PHENYL)ETHYL]-2-OXO-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE'>GMR</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvx OCA], [https://pdbe.org/4yvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yvx RCSB], [https://www.ebi.ac.uk/pdbsum/4yvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yvx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 23: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Hu X]] | ||
[[Category: | [[Category: Zhang H]] | ||
[[Category: | [[Category: Zhao Y]] | ||
[[Category: | [[Category: Zheng X]] | ||
Latest revision as of 15:40, 8 November 2023
Crystal structure of AKR1C3 complexed with glimepiride
| ||||||||||||
