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==Truncated tetramerization domain of zebrafish p53 (crystal form I)==
==Truncated tetramerization domain of zebrafish p53 (crystal form I)==
<StructureSection load='4cz5' size='340' side='right' caption='[[4cz5]], [[Resolution|resolution]] 1.02&Aring;' scene=''>
<StructureSection load='4cz5' size='340' side='right'caption='[[4cz5]], [[Resolution|resolution]] 1.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cz5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CZ5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cz5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CZ5 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cz6|4cz6]], [[4cz7|4cz7]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.02&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cz5 OCA], [http://pdbe.org/4cz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cz5 RCSB], [http://www.ebi.ac.uk/pdbsum/4cz5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cz5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cz5 OCA], [https://pdbe.org/4cz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cz5 RCSB], [https://www.ebi.ac.uk/pdbsum/4cz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cz5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/G1K2L5_DANRE G1K2L5_DANRE]] Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).[RuleBase:RU003304]
[https://www.uniprot.org/uniprot/P53_DANRE P53_DANRE] Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.<ref>PMID:12477391</ref> <ref>PMID:15630097</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Joerger, A C]]
[[Category: Danio rerio]]
[[Category: Cell cycle]]
[[Category: Large Structures]]
[[Category: P53 family]]
[[Category: Joerger AC]]
[[Category: Protein evolution]]
[[Category: Transcription factor]]
[[Category: Tumor suppressor]]
Retrieved from "https://proteopedia.org/4cz5"