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==Mouse Cereblon thalidomide binding domain, native==
==Mouse Cereblon thalidomide binding domain, native==
<StructureSection load='3wx2' size='340' side='right' caption='[[3wx2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3wx2' size='340' side='right'caption='[[3wx2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3wx2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WX2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3wx2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WX2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wx1|3wx1]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wx2 OCA], [http://pdbe.org/3wx2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wx2 RCSB], [http://www.ebi.ac.uk/pdbsum/3wx2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wx2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wx2 OCA], [https://pdbe.org/3wx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wx2 RCSB], [https://www.ebi.ac.uk/pdbsum/3wx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wx2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CRBN_MOUSE CRBN_MOUSE]] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity).  
[https://www.uniprot.org/uniprot/CRBN_MOUSE CRBN_MOUSE] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3wx2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3wx2" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hakoshima, T]]
[[Category: Large Structures]]
[[Category: Handa, H]]
[[Category: Mus musculus]]
[[Category: Hirano, Y]]
[[Category: Hakoshima T]]
[[Category: Ito, T]]
[[Category: Handa H]]
[[Category: Mori, T]]
[[Category: Hirano Y]]
[[Category: Yamaguchi, Y]]
[[Category: Ito T]]
[[Category: E3 ubiquitin ligase]]
[[Category: Mori T]]
[[Category: Metal binding protein]]
[[Category: Yamaguchi Y]]
[[Category: Zinc finger]]
Retrieved from "https://proteopedia.org/3wx2"