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==X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with cyanoselenobarbital (seleniated barbiturate)==
==X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with cyanoselenobarbital (seleniated barbiturate)==
<StructureSection load='5l47' size='340' side='right' caption='[[5l47]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='5l47' size='340' side='right'caption='[[5l47]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5l47]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L47 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5l47]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter Gloeobacter]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L47 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6JA:2-[5-ETHYL-2,4,6-TRIS(OXIDANYLIDENE)-1,3-DIAZINAN-5-YL]ETHYL+SELENOCYANATE'>6JA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l47 OCA], [http://pdbe.org/5l47 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l47 RCSB], [http://www.ebi.ac.uk/pdbsum/5l47 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l47 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6JA:2-[5-ETHYL-2,4,6-TRIS(OXIDANYLIDENE)-1,3-DIAZINAN-5-YL]ETHYL+SELENOCYANATE'>6JA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l47 OCA], [https://pdbe.org/5l47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l47 RCSB], [https://www.ebi.ac.uk/pdbsum/5l47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l47 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5l47" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5l47" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Delarue, M]]
[[Category: Gloeobacter]]
[[Category: Fourati, Z]]
[[Category: Large Structures]]
[[Category: Ruza, R Reinholds]]
[[Category: Delarue M]]
[[Category: Membrane protein]]
[[Category: Fourati Z]]
[[Category: Transport protein]]
[[Category: Reinholds Ruza R]]
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