5mmu: Difference between revisions
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==NMR solution structure of the major apple allergen Mal d 1== | |||
<StructureSection load='5mmu' size='340' side='right'caption='[[5mmu]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5mmu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Malus_domestica Malus domestica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MMU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mmu OCA], [https://pdbe.org/5mmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mmu RCSB], [https://www.ebi.ac.uk/pdbsum/5mmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mmu ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MAL11_MALDO MAL11_MALDO] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
More than 70% of birch pollen-allergic patients develop allergic cross-reactions to the major allergen found in apple fruits (Malus domestica), the 17.5 kDa protein Mal d 1. Allergic reactions against this protein result from initial sensitization to the major allergen from birch pollen, Bet v 1. Immunologic cross-reactivity of Bet v 1-specific IgE antibodies with Mal d 1 after apple consumption can subsequently provoke severe oral allergic syndromes. This study presents the three-dimensional NMR solution structure of Mal d 1 (isoform Mal d 1.0101, initially cloned from 'Granny Smith' apples). This protein is composed of a seven-stranded antiparallel beta-sheet and three alpha-helices that form a large internal cavity, similar to Bet v 1 and other cross-reactive food allergens. The Mal d 1 structure provides the basis for elucidating the details of allergic cross-reactivity between birch pollen and apple allergens on a molecular level. | |||
Structure of the Major Apple Allergen Mal d 1.,Ahammer L, Grutsch S, Kamenik AS, Liedl KR, Tollinger M J Agric Food Chem. 2017 Mar 1;65(8):1606-1612. doi: 10.1021/acs.jafc.6b05752., Epub 2017 Feb 15. PMID:28161953<ref>PMID:28161953</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Ahammer | <div class="pdbe-citations 5mmu" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: Kamenik | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Malus domestica]] | |||
[[Category: Ahammer L]] | |||
[[Category: Grutsch S]] | |||
[[Category: Kamenik AS]] | |||
[[Category: Liedl KR]] | |||
[[Category: Tollinger M]] | |||
Latest revision as of 17:40, 8 November 2023
NMR solution structure of the major apple allergen Mal d 1
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