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==Crystal structure of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with high affinity inhibitory peptide from serine acetyl transferase of Salmonella typhimurium at 2.0 A==
==Crystal structure of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with high affinity inhibitory peptide from serine acetyl transferase of Salmonella typhimurium at 2.0 A==
<StructureSection load='4nu8' size='340' side='right' caption='[[4nu8]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
<StructureSection load='4nu8' size='340' side='right'caption='[[4nu8]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nu8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NU8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nu8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20] and [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhi Salmonella enterica subsp. enterica serovar Typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NU8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_synthase Cysteine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.47 2.5.1.47] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nu8 OCA], [https://pdbe.org/4nu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nu8 RCSB], [https://www.ebi.ac.uk/pdbsum/4nu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nu8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nu8 OCA], [http://pdbe.org/4nu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nu8 RCSB], [http://www.ebi.ac.uk/pdbsum/4nu8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nu8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CYSK_HAEIN CYSK_HAEIN]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cysteine synthase]]
[[Category: Haemophilus influenzae Rd KW20]]
[[Category: Ekka, M K]]
[[Category: Large Structures]]
[[Category: Kaushik, A]]
[[Category: Salmonella enterica subsp. enterica serovar Typhi]]
[[Category: Kumaran, S]]
[[Category: Ekka MK]]
[[Category: Singh, A K]]
[[Category: Kaushik A]]
[[Category: Alpha/beta fold]]
[[Category: Kumaran S]]
[[Category: Catalytic activity cysteine synthase]]
[[Category: Singh AK]]
[[Category: Rossmann fold cysk]]
[[Category: Serine acetyl transferase]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]

Latest revision as of 14:50, 8 November 2023

Crystal structure of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with high affinity inhibitory peptide from serine acetyl transferase of Salmonella typhimurium at 2.0 A

4nu8, resolution 2.07Å

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