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==Structure of the nine-bladed beta-propeller of eIF3b==
==Structure of the nine-bladed beta-propeller of eIF3b==
<StructureSection load='4nox' size='340' side='right' caption='[[4nox]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
<StructureSection load='4nox' size='340' side='right'caption='[[4nox]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nox]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NOX FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nox]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NOX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.722&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nox OCA], [http://pdbe.org/4nox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nox RCSB], [http://www.ebi.ac.uk/pdbsum/4nox PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nox ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nox OCA], [https://pdbe.org/4nox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nox RCSB], [https://www.ebi.ac.uk/pdbsum/4nox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nox ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/G0RXS6_CHATD G0RXS6_CHATD]] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome (By similarity).[PIRNR:PIRNR036424][HAMAP-Rule:MF_03001]  
[https://www.uniprot.org/uniprot/G0RXS6_CHATD G0RXS6_CHATD] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome (By similarity).[PIRNR:PIRNR036424][HAMAP-Rule:MF_03001]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The multisubunit eukaryotic translation initiation factor 3, among which the subunit b (eIF3b) is a major scaffold protein, plays essential roles in protein synthesis. Here, we report the crystal structure of the WD40 domain of Chaetomium thermophilum eIF3b, revealing a nine-bladed beta-propeller fold. Sequence analysis indicates that this propeller architecture is common to all eIF3b orthologs. Revisiting the cryoelectron microscopy (cryo-EM) map of the 43S preinitiation complex suggests an interaction of the eIF3b with the 40S ribosomal subunit involving the ribosomal protein S9e and the 18S rRNA. This model is strongly supported by the direct binding of eIF3b to 40S ribosomes and to the isolated ribosomal protein rpS9e in vitro.
 
Translation initiation factor eIF3b contains a nine-bladed beta-propeller and interacts with the 40S ribosomal subunit.,Liu Y, Neumann P, Kuhle B, Monecke T, Schell S, Chari A, Ficner R Structure. 2014 Jun 10;22(6):923-30. doi: 10.1016/j.str.2014.03.010. Epub 2014, Apr 24. PMID:24768115<ref>PMID:24768115</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4nox" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Eukaryotic initiation factor|Eukaryotic initiation factor]]
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ficner, R]]
[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
[[Category: Kuhle, B]]
[[Category: Large Structures]]
[[Category: Liu, Y]]
[[Category: Ficner R]]
[[Category: Monecke, T]]
[[Category: Kuhle B]]
[[Category: Neumann, P]]
[[Category: Liu Y]]
[[Category: Beta propeller]]
[[Category: Monecke T]]
[[Category: Translation]]
[[Category: Neumann P]]

Latest revision as of 08:57, 20 March 2024

Structure of the nine-bladed beta-propeller of eIF3b

4nox, resolution 2.72Å

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