5ue1: Difference between revisions
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New page: '''Unreleased structure''' The entry 5ue1 is ON HOLD Authors: Filippova, E.V., Minasov, G., Shuvalova, L., Kiryukhina, O., Dubrovska, I., Grimshaw, S., Anderson, W.F., Center for Struct... |
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==Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase in complex with adenine from Vibrio fischeri ES114== | |||
<StructureSection load='5ue1' size='340' side='right'caption='[[5ue1]], [[Resolution|resolution]] 1.14Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ue1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aliivibrio_fischeri_ES114 Aliivibrio fischeri ES114]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UE1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.14Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9DA:9-DEAZAADENINE'>9DA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ue1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ue1 OCA], [https://pdbe.org/5ue1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ue1 RCSB], [https://www.ebi.ac.uk/pdbsum/5ue1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ue1 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/MTNN_ALIF1 MTNN_ALIF1] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.[HAMAP-Rule:MF_01684] | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Aliivibrio fischeri ES114]] | ||
[[Category: Shuvalova | [[Category: Large Structures]] | ||
[[Category: Anderson WF]] | |||
[[Category: Dubrovska I]] | |||
[[Category: Filippova EV]] | |||
[[Category: Grimshaw S]] | |||
[[Category: Kiryukhina O]] | |||
[[Category: Minasov G]] | |||
[[Category: Shuvalova L]] | |||
Latest revision as of 13:26, 4 October 2023
Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase in complex with adenine from Vibrio fischeri ES114
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