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==Human PARP10 (ARTD10), catalytic fragment in complex with PARP inhibitor Veliparib==
==Human PARP10 (ARTD10), catalytic fragment in complex with PARP inhibitor Veliparib==
<StructureSection load='5lx6' size='340' side='right' caption='[[5lx6]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
<StructureSection load='5lx6' size='340' side='right'caption='[[5lx6]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5lx6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LX6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5lx6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LX6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=78P:(2R)-2-(7-CARBAMOYL-1H-BENZIMIDAZOL-2-YL)-2-METHYLPYRROLIDINIUM'>78P</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=78P:(2R)-2-(7-CARBAMOYL-1H-BENZIMIDAZOL-2-YL)-2-METHYLPYRROLIDINIUM'>78P</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lx6 OCA], [http://pdbe.org/5lx6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lx6 RCSB], [http://www.ebi.ac.uk/pdbsum/5lx6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lx6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lx6 OCA], [https://pdbe.org/5lx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lx6 RCSB], [https://www.ebi.ac.uk/pdbsum/5lx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lx6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PAR10_HUMAN PAR10_HUMAN]] May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.<ref>PMID:15674325</ref> <ref>PMID:16455663</ref>
[https://www.uniprot.org/uniprot/PAR10_HUMAN PAR10_HUMAN] May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.<ref>PMID:15674325</ref> <ref>PMID:16455663</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5lx6" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5lx6" style="background-color:#fffaf0;"></div>
==See Also==
*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Karlberg, T]]
[[Category: Homo sapiens]]
[[Category: Schuler, H]]
[[Category: Large Structures]]
[[Category: Thorsell, A G]]
[[Category: Karlberg T]]
[[Category: Adp-ribosylation]]
[[Category: Schuler H]]
[[Category: Parp inhibitor]]
[[Category: Thorsell AG]]
[[Category: Transferase]]
[[Category: Transferase domain]]
Retrieved from "https://proteopedia.org/5lx6"