5mrl: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:


==Crystal structure of human monoamine oxidase B (MAO B) in complex with N(Furan2ylmethyl)Nmethylprop2yn1amine (F2MPA)==
==Crystal structure of human monoamine oxidase B (MAO B) in complex with N(Furan2ylmethyl)Nmethylprop2yn1amine (F2MPA)==
<StructureSection load='5mrl' size='340' side='right' caption='[[5mrl]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
<StructureSection load='5mrl' size='340' side='right'caption='[[5mrl]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5mrl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MRL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MRL FirstGlance]. <br>
<table><tr><td colspan='2'>[[5mrl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MRL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F2M:(~{E})-~{N}-(FURAN-2-YLMETHYL)-~{N}-METHYL-PROP-1-EN-1-AMINE'>F2M</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F2M:(~{E})-~{N}-(FURAN-2-YLMETHYL)-~{N}-METHYL-PROP-1-EN-1-AMINE'>F2M</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mrl OCA], [http://pdbe.org/5mrl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mrl RCSB], [http://www.ebi.ac.uk/pdbsum/5mrl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mrl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mrl OCA], [https://pdbe.org/5mrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mrl RCSB], [https://www.ebi.ac.uk/pdbsum/5mrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mrl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN]] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.  
[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 5mrl" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5mrl" style="background-color:#fffaf0;"></div>
==See Also==
*[[Monoamine oxidase|Monoamine oxidase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Monoamine oxidase]]
[[Category: Homo sapiens]]
[[Category: Binda, C]]
[[Category: Large Structures]]
[[Category: Corne, R]]
[[Category: Binda C]]
[[Category: Deurwaerdere, P De]]
[[Category: Corne R]]
[[Category: Fall, Y]]
[[Category: De Deurwaerdere P]]
[[Category: Leone, C]]
[[Category: Fall Y]]
[[Category: Marco-Contelles, J]]
[[Category: Leone C]]
[[Category: Ramsay, R R]]
[[Category: Marco-Contelles J]]
[[Category: Valeri, A]]
[[Category: Ramsay RR]]
[[Category: Valoti, M]]
[[Category: Valeri A]]
[[Category: Enzyme]]
[[Category: Valoti M]]
[[Category: Inhibitor]]
[[Category: Neurodegeneration]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/5mrl"