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==Structure of Calcineurin in complex with NFATc1 LxVP peptide==
==Structure of Calcineurin in complex with NFATc1 LxVP peptide==
<StructureSection load='5sve' size='340' side='right' caption='[[5sve]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5sve' size='340' side='right'caption='[[5sve]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5sve]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SVE FirstGlance]. <br>
<table><tr><td colspan='2'>[[5sve]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SVE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.596&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5sve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sve OCA], [http://pdbe.org/5sve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5sve RCSB], [http://www.ebi.ac.uk/pdbsum/5sve PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5sve ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sve OCA], [https://pdbe.org/5sve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sve RCSB], [https://www.ebi.ac.uk/pdbsum/5sve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sve ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN]] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref> [[http://www.uniprot.org/uniprot/CANB1_HUMAN CANB1_HUMAN]] Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
[https://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5sve" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5sve" style="background-color:#fffaf0;"></div>
==See Also==
*[[Calcineurin 3D structures|Calcineurin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Phosphoprotein phosphatase]]
[[Category: Homo sapiens]]
[[Category: Page, R]]
[[Category: Large Structures]]
[[Category: Peti, W]]
[[Category: Page R]]
[[Category: Sheftic, S R]]
[[Category: Peti W]]
[[Category: Hydrolase]]
[[Category: Sheftic SR]]
[[Category: Protein binding]]
Retrieved from "https://proteopedia.org/5sve"