4p14: Difference between revisions

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==Crystal structure of Canavalia brasiliensis (ConBr) complexed with adenine==
==Crystal structure of Canavalia brasiliensis (ConBr) complexed with adenine==
<StructureSection load='4p14' size='340' side='right' caption='[[4p14]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4p14' size='340' side='right'caption='[[4p14]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4p14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_brasiliensis Canavalia brasiliensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P14 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4p14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_brasiliensis Canavalia brasiliensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P14 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p14 OCA], [http://pdbe.org/4p14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p14 RCSB], [http://www.ebi.ac.uk/pdbsum/4p14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p14 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p14 OCA], [https://pdbe.org/4p14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p14 RCSB], [https://www.ebi.ac.uk/pdbsum/4p14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p14 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CONA_CANBR CONA_CANBR]] Glucose/D-mannose specific lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
[https://www.uniprot.org/uniprot/CONA_CANBR CONA_CANBR] Glucose/D-mannose specific lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>  
 
==See Also==
*[[Concanavalin 3D structures|Concanavalin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Canavalia brasiliensis]]
[[Category: Canavalia brasiliensis]]
[[Category: Cavada, B S]]
[[Category: Large Structures]]
[[Category: Delatorre, P]]
[[Category: Cavada BS]]
[[Category: Holanda, E]]
[[Category: Delatorre P]]
[[Category: Leal, R B]]
[[Category: Holanda E]]
[[Category: Nagano, C S]]
[[Category: Leal RB]]
[[Category: Nascimento, K S]]
[[Category: Nagano CS]]
[[Category: Neto, I L.B]]
[[Category: Nascimento KS]]
[[Category: Nobrega, R B]]
[[Category: Neto ILB]]
[[Category: Rocha, B A.M]]
[[Category: Nobrega RB]]
[[Category: Sampaio, A H]]
[[Category: Rocha BAM]]
[[Category: Silva-Filho, J C]]
[[Category: Sampaio AH]]
[[Category: Teixeira, C S]]
[[Category: Silva-Filho JC]]
[[Category: Adenine]]
[[Category: Teixeira CS]]
[[Category: Lectin]]
[[Category: Sugar binding protein]]

Latest revision as of 07:08, 27 September 2023

Crystal structure of Canavalia brasiliensis (ConBr) complexed with adenine

4p14, resolution 2.00Å

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