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==Crystal structure of the gamma-secretase component Nicastrin==
==Crystal structure of the gamma-secretase component Nicastrin==
<StructureSection load='4r12' size='340' side='right' caption='[[4r12]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4r12' size='340' side='right'caption='[[4r12]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4r12]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R12 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4r12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_purpureum Dictyostelium purpureum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R12 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r12 OCA], [http://pdbe.org/4r12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r12 RCSB], [http://www.ebi.ac.uk/pdbsum/4r12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r12 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r12 OCA], [https://pdbe.org/4r12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r12 RCSB], [https://www.ebi.ac.uk/pdbsum/4r12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r12 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NICA_DICPU NICA_DICPU] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).[UniProtKB:Q92542]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4r12" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4r12" style="background-color:#fffaf0;"></div>
==See Also==
*[[Gamma secretase|Gamma secretase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lu, P]]
[[Category: Dictyostelium purpureum]]
[[Category: Ma, D]]
[[Category: Large Structures]]
[[Category: Shi, Y]]
[[Category: Lu P]]
[[Category: Sun, L]]
[[Category: Ma D]]
[[Category: Xie, T]]
[[Category: Shi Y]]
[[Category: Yan, C]]
[[Category: Sun L]]
[[Category: Yang, G]]
[[Category: Xie T]]
[[Category: Zhao, Y]]
[[Category: Yan C]]
[[Category: Zhou, R]]
[[Category: Yang G]]
[[Category: Alpha/beta]]
[[Category: Zhao Y]]
[[Category: Gamma-secretase complex]]
[[Category: Zhou R]]
[[Category: Nicastrin]]
[[Category: Protein binding]]
[[Category: Putative substrate-recruiting component]]
Retrieved from "https://proteopedia.org/4r12"