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==Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase in complex with adenine from Vibrio fischeri ES114==
==Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase in complex with adenine from Vibrio fischeri ES114==
<StructureSection load='5ue1' size='340' side='right' caption='[[5ue1]], [[Resolution|resolution]] 1.14&Aring;' scene=''>
<StructureSection load='5ue1' size='340' side='right'caption='[[5ue1]], [[Resolution|resolution]] 1.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ue1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UE1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ue1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aliivibrio_fischeri_ES114 Aliivibrio fischeri ES114]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UE1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9DA:9-DEAZAADENINE'>9DA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.14&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylhomocysteine_nucleosidase Adenosylhomocysteine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.9 3.2.2.9] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9DA:9-DEAZAADENINE'>9DA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ue1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ue1 OCA], [http://pdbe.org/5ue1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ue1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ue1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ue1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ue1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ue1 OCA], [https://pdbe.org/5ue1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ue1 RCSB], [https://www.ebi.ac.uk/pdbsum/5ue1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ue1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MTNN_VIBF1 MTNN_VIBF1]] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  
[https://www.uniprot.org/uniprot/MTNN_ALIF1 MTNN_ALIF1] Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.[HAMAP-Rule:MF_01684]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Adenosylhomocysteine nucleosidase]]
[[Category: Aliivibrio fischeri ES114]]
[[Category: Anderson, W F]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Anderson WF]]
[[Category: Dubrovska, I]]
[[Category: Dubrovska I]]
[[Category: Filippova, E V]]
[[Category: Filippova EV]]
[[Category: Grimshaw, S]]
[[Category: Grimshaw S]]
[[Category: Kiryukhina, O]]
[[Category: Kiryukhina O]]
[[Category: Minasov, G]]
[[Category: Minasov G]]
[[Category: Shuvalova, L]]
[[Category: Shuvalova L]]
[[Category: Csgid]]
[[Category: Hydrolase]]
[[Category: Nuclear protein]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/5ue1"