4usg: Difference between revisions

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==Crystal structure of PC4 W89Y mutant complex with DNA==
==Crystal structure of PC4 W89Y mutant complex with DNA==
<StructureSection load='4usg' size='340' side='right' caption='[[4usg]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
<StructureSection load='4usg' size='340' side='right'caption='[[4usg]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4usg]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4USG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4USG FirstGlance]. <br>
<table><tr><td colspan='2'>[[4usg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4USG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4USG FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4usg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4usg OCA], [http://pdbe.org/4usg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4usg RCSB], [http://www.ebi.ac.uk/pdbsum/4usg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4usg ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.973&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4usg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4usg OCA], [https://pdbe.org/4usg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4usg RCSB], [https://www.ebi.ac.uk/pdbsum/4usg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4usg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TCP4_HUMAN TCP4_HUMAN]] General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).<ref>PMID:8062392</ref> <ref>PMID:8062391</ref> <ref>PMID:7628453</ref> <ref>PMID:9482861</ref> <ref>PMID:16689930</ref> <ref>PMID:9360603</ref> <ref>PMID:16605275</ref>
[https://www.uniprot.org/uniprot/TCP4_HUMAN TCP4_HUMAN] General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).<ref>PMID:8062392</ref> <ref>PMID:8062391</ref> <ref>PMID:7628453</ref> <ref>PMID:9482861</ref> <ref>PMID:16689930</ref> <ref>PMID:9360603</ref> <ref>PMID:16605275</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Liu, J]]
[[Category: Homo sapiens]]
[[Category: Zhao, Y]]
[[Category: Large Structures]]
[[Category: Transcription]]
[[Category: Liu J]]
[[Category: Zhao Y]]