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==Crystal structure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant==
==Crystal structure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant==
<StructureSection load='4s0v' size='340' side='right' caption='[[4s0v]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4s0v' size='340' side='right'caption='[[4s0v]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4s0v]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4rnb 4rnb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S0V FirstGlance]. <br>
<table><tr><td colspan='2'>[[4s0v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4rnb 4rnb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S0V FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SUV:[(7R)-4-(5-CHLORO-1,3-BENZOXAZOL-2-YL)-7-METHYL-1,4-DIAZEPAN-1-YL][5-METHYL-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL]METHANONE'>SUV</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0v OCA], [http://pdbe.org/4s0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s0v RCSB], [http://www.ebi.ac.uk/pdbsum/4s0v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0v ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SUV:[(7R)-4-(5-CHLORO-1,3-BENZOXAZOL-2-YL)-7-METHYL-1,4-DIAZEPAN-1-YL][5-METHYL-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL]METHANONE'>SUV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0v OCA], [https://pdbe.org/4s0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s0v RCSB], [https://www.ebi.ac.uk/pdbsum/4s0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/OX2R_HUMAN OX2R_HUMAN]] Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.  
[https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB] [https://www.uniprot.org/uniprot/OX2R_HUMAN OX2R_HUMAN] Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4s0v" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4s0v" style="background-color:#fffaf0;"></div>
==See Also==
*[[Orexin and Orexin receptor|Orexin and Orexin receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Kolb, P]]
[[Category: Homo sapiens]]
[[Category: Mobarec, J C]]
[[Category: Large Structures]]
[[Category: Rosenbaum, D M]]
[[Category: Pyrococcus abyssi GE5]]
[[Category: Yin, J]]
[[Category: Kolb P]]
[[Category: G protein-coupled receptor]]
[[Category: Mobarec JC]]
[[Category: N-linked glycosylation]]
[[Category: Rosenbaum DM]]
[[Category: Orexin neurotransmitter]]
[[Category: Yin J]]
[[Category: Orexin receptor]]
[[Category: Orexin-a]]
[[Category: Orexin-b]]
[[Category: Signaling protein]]
[[Category: Suvorexant]]
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