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==mGluR2 ECD and mGluR3 ECD complex with ligands==
==mGluR2 ECD and mGluR3 ECD complex with ligands==
<StructureSection load='4xar' size='340' side='right' caption='[[4xar]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
<StructureSection load='4xar' size='340' side='right'caption='[[4xar]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4xar]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XAR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XAR FirstGlance]. <br>
<table><tr><td colspan='2'>[[4xar]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XAR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40F:(1S,2S,5R,6S)-2-AMINOBICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC+ACID'>40F</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xaq|4xaq]], [[4xas|4xas]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=40F:(1S,2S,5R,6S)-2-AMINOBICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC+ACID'>40F</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xar OCA], [http://pdbe.org/4xar PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xar RCSB], [http://www.ebi.ac.uk/pdbsum/4xar PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xar ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xar OCA], [https://pdbe.org/4xar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xar RCSB], [https://www.ebi.ac.uk/pdbsum/4xar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xar ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref>
[https://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Metabotropic glutamate receptor|Metabotropic glutamate receptor]]
*[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Clawson, D K]]
[[Category: Homo sapiens]]
[[Category: Mglur2 mglur3 ecd]]
[[Category: Large Structures]]
[[Category: Signaling protein]]
[[Category: Clawson DK]]
Retrieved from "https://proteopedia.org/4xar"