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==Mutant (D415G) GH97 alpha-galactosidase in complex with Gal-Lac==
==Mutant (D415G) GH97 alpha-galactosidase in complex with Gal-Lac==
<StructureSection load='5e1q' size='340' side='right' caption='[[5e1q]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
<StructureSection load='5e1q' size='340' side='right'caption='[[5e1q]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5e1q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E1Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E1Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[5e1q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E1Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E1Q FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LAT:BETA-LACTOSE'>LAT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.943&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-galactosidase Alpha-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.22 3.2.1.22] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e1q OCA], [http://pdbe.org/5e1q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e1q RCSB], [http://www.ebi.ac.uk/pdbsum/5e1q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e1q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e1q OCA], [https://pdbe.org/5e1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e1q RCSB], [https://www.ebi.ac.uk/pdbsum/5e1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e1q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AGAL_BACTN AGAL_BACTN]] Galactosidase that is able to hydrolyze the alpha-1,6 disaccharide melibiose and the synthetic p-nitrophenyl alpha-galactoside substrate (pNP-Gal), with retention of the anomeric configuration. Does not hydrolyze DNP-Glc or pNP-Glc.<ref>PMID:18848471</ref> <ref>PMID:19646996</ref>
[https://www.uniprot.org/uniprot/AGAL_BACTN AGAL_BACTN] Galactosidase that is able to hydrolyze the alpha-1,6 disaccharide melibiose and the synthetic p-nitrophenyl alpha-galactoside substrate (pNP-Gal), with retention of the anomeric configuration. Does not hydrolyze DNP-Glc or pNP-Glc.<ref>PMID:18848471</ref> <ref>PMID:19646996</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5e1q" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5e1q" style="background-color:#fffaf0;"></div>
==See Also==
*[[Galactosidase 3D structures|Galactosidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Alpha-galactosidase]]
[[Category: Bacteroides thetaiotaomicron VPI-5482]]
[[Category: Kimura, A]]
[[Category: Large Structures]]
[[Category: Matsunaga, K]]
[[Category: Kimura A]]
[[Category: Okuyama, M]]
[[Category: Matsunaga K]]
[[Category: Tagami, T]]
[[Category: Okuyama M]]
[[Category: Yamashita, K]]
[[Category: Tagami T]]
[[Category: Yao, M]]
[[Category: Yamashita K]]
[[Category: Hydrolase]]
[[Category: Yao M]]
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