5ukz: Difference between revisions

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'''Unreleased structure'''


The entry 5ukz is ON HOLD
==NMR Solution structure of chemically synthesized antilisterial Pediocin PA-1 M31L analog.==
<StructureSection load='5ukz' size='340' side='right'caption='[[5ukz]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ukz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pediococcus_acidilactici Pediococcus acidilactici]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UKZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ukz OCA], [https://pdbe.org/5ukz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ukz RCSB], [https://www.ebi.ac.uk/pdbsum/5ukz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ukz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PPA1_PEDAC PPA1_PEDAC] Bactericidal activity (effective inhibitor of L.monocytogenes).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The antimicrobial peptide pediocin PA-1 is a class IIa bacteriocin that inhibits several clinically relevant pathogens including Listeria spp. Here we report the synthesis and characterization of whole pediocin PA-1 and novel analogs thereof using a combination of solid- and solution-phase strategies to overcome difficulties due to instability and undesired reactions. Pediocin PA-1 thus synthesized was a potent inhibitor of Listeria monocytogenes (MIC = 6.8 nM), similar to the bacteriocin produced naturally by Pediococcus acidilactici. Of particular interest is that linear analogs lacking both of the disulfide bridges characterizing pediocin PA-1 were as potent. One linear analog was also a strong inhibitor of Clostridium perfringens, another important food-borne pathogen. These results are discussed in light of conformational information derived from circular dichroism, solution NMR spectroscopy and structure-activity relationship studies.


Authors:  
Synthesis, antimicrobial activity and conformational analysis of the class IIa bacteriocin pediocin PA-1 and analogs thereof.,Bedard F, Hammami R, Zirah S, Rebuffat S, Fliss I, Biron E Sci Rep. 2018 Jun 13;8(1):9029. doi: 10.1038/s41598-018-27225-3. PMID:29899567<ref>PMID:29899567</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 5ukz" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pediococcus acidilactici]]
[[Category: Bedard F]]
[[Category: Biron E]]
[[Category: Fliss I]]
[[Category: Hammami R]]
[[Category: Rebuffat S]]
[[Category: Zirah S]]
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