5ula: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: '''Unreleased structure''' The entry 5ula is ON HOLD Authors: Plotnikov, A.N., Joshua, j., Zhou, M.-M. Description: Crystal structure of the first bromodomain of human BRD4 in complex ...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 5ula is ON HOLD
==Crystal Structure of the First Bromodomain of Human BRD4 in Complex With Cyclic Vinylogous Amide Inhibitor MS402==
<StructureSection load='5ula' size='340' side='right'caption='[[5ula]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ula]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ULA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ULA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5MJ:3-CHLORANYL-~{N}-(4-METHOXYPHENYL)-4-[(2-METHYL-3-OXIDANYLIDENE-CYCLOPENTEN-1-YL)AMINO]BENZAMIDE'>5MJ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ula FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ula OCA], [https://pdbe.org/5ula PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ula RCSB], [https://www.ebi.ac.uk/pdbsum/5ula PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ula ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


Authors: Plotnikov, A.N., Joshua, j., Zhou, M.-M.
==See Also==
 
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
Description: Crystal structure of the first bromodomain of human BRD4 in complex with MS402
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Plotnikov, A.N]]
__TOC__
[[Category: Zhou, M.-M]]
</StructureSection>
[[Category: Joshua, J]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Joshua j]]
[[Category: Plotnikov AN]]
[[Category: Zhou M-M]]
Retrieved from "https://proteopedia.org/5ula"