5ulf: Difference between revisions

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New page: '''Unreleased structure''' The entry 5ulf is ON HOLD Authors: Middleton, A.J., Day, C.L., Wright, J.D. Description: Crystal Structure of a UbcH5b~Ub conjugate [[Category: Unreleased St...
 
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'''Unreleased structure'''


The entry 5ulf is ON HOLD
==Crystal Structure of a UbcH5b~Ub conjugate==
<StructureSection load='5ulf' size='340' side='right'caption='[[5ulf]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5ulf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ULF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ULF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ulf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ulf OCA], [https://pdbe.org/5ulf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ulf RCSB], [https://www.ebi.ac.uk/pdbsum/5ulf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ulf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UB2D2_HUMAN UB2D2_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.<ref>PMID:10329681</ref> <ref>PMID:15280377</ref> <ref>PMID:18042044</ref> <ref>PMID:18703417</ref> <ref>PMID:18359941</ref> <ref>PMID:19854139</ref> <ref>PMID:20403326</ref> <ref>PMID:20061386</ref>


Authors: Middleton, A.J., Day, C.L., Wright, J.D.
==See Also==
 
*[[3D structures of ubiquitin|3D structures of ubiquitin]]
Description: Crystal Structure of a UbcH5b~Ub conjugate
*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
[[Category: Unreleased Structures]]
== References ==
[[Category: Wright, J.D]]
<references/>
[[Category: Day, C.L]]
__TOC__
[[Category: Middleton, A.J]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Day CL]]
[[Category: Middleton AJ]]
[[Category: Wright JD]]
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