5ml3: Difference between revisions
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==The crystal structure of PDE6D in complex to Deltasonamide1== | ==The crystal structure of PDE6D in complex to Deltasonamide1== | ||
<StructureSection load='5ml3' size='340' side='right' caption='[[5ml3]], [[Resolution|resolution]] 1.40Å' scene=''> | <StructureSection load='5ml3' size='340' side='right'caption='[[5ml3]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ml3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ML3 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5ml3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ML3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ML3 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DL3:~{N}1-[(4-CHLOROPHENYL)METHYL]-~{N}1-CYCLOPENTYL-~{N}4-[[2-(METHYLAMINO)PYRIMIDIN-4-YL]METHYL]-~{N}4-(PIPERIDIN-4-YLMETHYL)BENZENE-1,4-DISULFONAMIDE'>DL3</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DL3:~{N}1-[(4-CHLOROPHENYL)METHYL]-~{N}1-CYCLOPENTYL-~{N}4-[[2-(METHYLAMINO)PYRIMIDIN-4-YL]METHYL]-~{N}4-(PIPERIDIN-4-YLMETHYL)BENZENE-1,4-DISULFONAMIDE'>DL3</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ml3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ml3 OCA], [https://pdbe.org/5ml3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ml3 RCSB], [https://www.ebi.ac.uk/pdbsum/5ml3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ml3 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 18: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 5ml3" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5ml3" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Fansa EK]] | ||
[[Category: | [[Category: Martin-Gago P]] | ||
[[Category: | [[Category: Waldmann H]] | ||
[[Category: | [[Category: Wittinghofer A]] | ||
Latest revision as of 18:49, 1 November 2023
The crystal structure of PDE6D in complex to Deltasonamide1
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