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==Crystal structure of adenosine A2A receptor bound to a novel triazole-carboximidamide antagonist==
==Crystal structure of adenosine A2A receptor bound to a novel triazole-carboximidamide antagonist==
<StructureSection load='5uig' size='340' side='right' caption='[[5uig]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='5uig' size='340' side='right'caption='[[5uig]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5uig]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UIG FirstGlance]. <br>
<table><tr><td colspan='2'>[[5uig]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UIG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8D1:5-AMINO-N-[(2-METHOXYPHENYL)METHYL]-2-(3-METHYLPHENYL)-2H-1,2,3-TRIAZOLE-4-CARBOXIMIDAMIDE'>8D1</scene>, <scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uig OCA], [http://pdbe.org/5uig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uig RCSB], [http://www.ebi.ac.uk/pdbsum/5uig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uig ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8D1:5-AMINO-N-[(2-METHOXYPHENYL)METHYL]-2-(3-METHYLPHENYL)-2H-1,2,3-TRIAZOLE-4-CARBOXIMIDAMIDE'>8D1</scene>, <scene name='pdbligand=EDT:{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC+ACID'>EDT</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uig OCA], [https://pdbe.org/5uig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uig RCSB], [https://www.ebi.ac.uk/pdbsum/5uig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uig ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN]] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.  
[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Adenosine A2A receptor|Adenosine A2A receptor]]
*[[Adenosine A2A receptor 3D structures|Adenosine A2A receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bachhawat, P]]
[[Category: Escherichia coli]]
[[Category: Ceska, T]]
[[Category: Homo sapiens]]
[[Category: Chu, M Ling-Hon]]
[[Category: Large Structures]]
[[Category: Kobilka, B]]
[[Category: Bachhawat P]]
[[Category: Kobilka, T S]]
[[Category: Ceska T]]
[[Category: Lebon, F]]
[[Category: Kobilka B]]
[[Category: Sands, Z]]
[[Category: Kobilka TS]]
[[Category: Sun, B]]
[[Category: Lebon F]]
[[Category: A2a receptor]]
[[Category: Ling-Hon Chu M]]
[[Category: Adenosine]]
[[Category: Sands Z]]
[[Category: Adenosine binding protein]]
[[Category: Sun B]]
[[Category: Allosteric]]
[[Category: Gpcr]]
[[Category: Parkinson's disease]]
[[Category: Vapor diffusion]]
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