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==Dynamic Undocking and the Quasi-Bound State as tools for Drug Design==
==Dynamic Undocking and the Quasi-Bound State as tools for Drug Design==
<StructureSection load='5fnc' size='340' side='right' caption='[[5fnc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='5fnc' size='340' side='right'caption='[[5fnc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5fnc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FNC FirstGlance]. <br>
<table><tr><td colspan='2'>[[5fnc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FNC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IEE:6-CHLORO-4-N-[(4-METHYLPHENYL)METHYL]PYRIMIDINE-+2,4-DIAMINE'>IEE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fnd|5fnd]], [[5fnf|5fnf]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IEE:6-CHLORO-4-N-[(4-METHYLPHENYL)METHYL]PYRIMIDINE-+2,4-DIAMINE'>IEE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fnc OCA], [http://pdbe.org/5fnc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fnc RCSB], [http://www.ebi.ac.uk/pdbsum/5fnc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fnc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fnc OCA], [https://pdbe.org/5fnc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fnc RCSB], [https://www.ebi.ac.uk/pdbsum/5fnc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fnc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fnc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fnc" style="background-color:#fffaf0;"></div>
==See Also==
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker, L M]]
[[Category: Homo sapiens]]
[[Category: Barril, X]]
[[Category: Large Structures]]
[[Category: Davis, B]]
[[Category: Baker LM]]
[[Category: Hubbard, R]]
[[Category: Barril X]]
[[Category: Luque, F J]]
[[Category: Davis B]]
[[Category: Matassova, N]]
[[Category: Hubbard R]]
[[Category: Murray, J]]
[[Category: Luque FJ]]
[[Category: Roughley, S]]
[[Category: Matassova N]]
[[Category: Ruiz-Carmona, S]]
[[Category: Murray J]]
[[Category: Schmidtke, P]]
[[Category: Roughley S]]
[[Category: Chaperone]]
[[Category: Ruiz-Carmona S]]
[[Category: Drug design]]
[[Category: Schmidtke P]]
[[Category: Hsp90]]
[[Category: Oncology]]
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