3pmw: Difference between revisions
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==Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator== | ==Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator== | ||
<StructureSection load='3pmw' size='340' side='right' caption='[[3pmw]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='3pmw' size='340' side='right'caption='[[3pmw]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3pmw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PMW OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[3pmw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PMW FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=G69:N-[(2S)-5-{[4-(HYDROXYMETHYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]METHYL}-2,3-DIHYDRO-1H-INDEN-2-YL]PROPANE-2-SULFONAMIDE'>G69</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=G69:N-[(2S)-5-{[4-(HYDROXYMETHYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]METHYL}-2,3-DIHYDRO-1H-INDEN-2-YL]PROPANE-2-SULFONAMIDE'>G69</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pmw OCA], [https://pdbe.org/3pmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pmw RCSB], [https://www.ebi.ac.uk/pdbsum/3pmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pmw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[ | *[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Brown | [[Category: Large Structures]] | ||
[[Category: Campbell | [[Category: Rattus norvegicus]] | ||
[[Category: Gillen | [[Category: Brown CI]] | ||
[[Category: Gillespie | [[Category: Campbell RA]] | ||
[[Category: Jamieson | [[Category: Gillen KJ]] | ||
[[Category: Kazemier | [[Category: Gillespie J]] | ||
[[Category: Kiczun | [[Category: Jamieson C]] | ||
[[Category: Lamont | [[Category: Kazemier B]] | ||
[[Category: Lyons | [[Category: Kiczun M]] | ||
[[Category: Maclean | [[Category: Lamont Y]] | ||
[[Category: Moir | [[Category: Lyons AJ]] | ||
[[Category: Morrow | [[Category: Maclean JKF]] | ||
[[Category: Pantling | [[Category: Moir EM]] | ||
[[Category: Rankovic | [[Category: Morrow JA]] | ||
[[Category: Smith | [[Category: Pantling J]] | ||
[[Category: Rankovic Z]] | |||
[[Category: Smith L]] | |||
