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==High resolution structure of mouse Cryptochrome 1==
==High resolution structure of mouse Cryptochrome 1==
<StructureSection load='5t5x' size='340' side='right' caption='[[5t5x]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
<StructureSection load='5t5x' size='340' side='right'caption='[[5t5x]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5t5x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T5X FirstGlance]. <br>
<table><tr><td colspan='2'>[[5t5x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T5X FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t5x OCA], [http://pdbe.org/5t5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t5x RCSB], [http://www.ebi.ac.uk/pdbsum/5t5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t5x ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t5x OCA], [https://pdbe.org/5t5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t5x RCSB], [https://www.ebi.ac.uk/pdbsum/5t5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t5x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CRY1_MOUSE CRY1_MOUSE]] Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.<ref>PMID:10428031</ref> <ref>PMID:16628007</ref> <ref>PMID:16478995</ref>
[https://www.uniprot.org/uniprot/CRY1_MOUSE CRY1_MOUSE] Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.<ref>PMID:10428031</ref> <ref>PMID:16628007</ref> <ref>PMID:16478995</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5t5x" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5t5x" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cryptochrome 3D structures|Cryptochrome 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Michael, A K]]
[[Category: Large Structures]]
[[Category: Partch, C L]]
[[Category: Mus musculus]]
[[Category: Tripathi, S]]
[[Category: Michael AK]]
[[Category: Circadian]]
[[Category: Partch CL]]
[[Category: Repressor]]
[[Category: Tripathi S]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/5t5x"