5mn3: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(5 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 5mn3 is ON HOLD  until Paper Publication
==NMR structure of the Littorina littorea metallothionein, a snail MT folding into three distinct domains==
<StructureSection load='5mn3' size='340' side='right'caption='[[5mn3]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5mn3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Littorina_littorea Littorina littorea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MN3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mn3 OCA], [https://pdbe.org/5mn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mn3 RCSB], [https://www.ebi.ac.uk/pdbsum/5mn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mn3 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
In this study, we present an NMR structure of the metallothionein (MT) from the snail Littorina littorea (LlMT) in complex with Cd2+ . LlMT is capable of binding 9 Zn2+ or 9 Cd2+ ions. Sequence alignments with other snail MTs revealed that the protein is likely composed of three domains. The study revealed that the protein is divided into three individual domains, each of which folds into a single well-defined three-metal cluster. The central alpha2 and C-terminal beta domains are positioned with a unique relative orientation. Two variants with longer and shorter linkers were investigated, which revealed that specific interdomain contacts only occurred with the wild-type linker. Moreover, a domain-swap mutant in which the highly similar alpha1 and alpha2 domains were exchanged was structurally almost identical. It is suggested that the expression of a three-domain MT confers an evolutionary advantage on Littorina littorea in terms of coping with Cd2+ stress and adverse environmental conditions.


Authors: Zerbe, O., Jurt, S., Baumann, C.
Structural Adaptation of a Protein to Increased Metal Stress: NMR Structure of a Marine Snail Metallothionein with an Additional Domain.,Baumann C, Beil A, Jurt S, Niederwanger M, Palacios O, Capdevila M, Atrian S, Dallinger R, Zerbe O Angew Chem Int Ed Engl. 2017 Apr 10;56(16):4617-4622. doi:, 10.1002/anie.201611873. Epub 2017 Mar 23. PMID:28332759<ref>PMID:28332759</ref>


Description: NMR structure of the Littorina littorea metallothionein, a snail MT folding into three distinct domains
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Zerbe, O]]
<div class="pdbe-citations 5mn3" style="background-color:#fffaf0;"></div>
[[Category: Jurt, S]]
== References ==
[[Category: Baumann, C]]
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Littorina littorea]]
[[Category: Baumann C]]
[[Category: Jurt S]]
[[Category: Zerbe O]]
Retrieved from "https://proteopedia.org/5mn3"