5tul: Difference between revisions
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==Crystal structure of tetracycline destructase Tet(55)== | |||
<StructureSection load='5tul' size='340' side='right'caption='[[5tul]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5tul]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Uncultured_bacterium Uncultured bacterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TUL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tul OCA], [https://pdbe.org/5tul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tul RCSB], [https://www.ebi.ac.uk/pdbsum/5tul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tul ProSAT]</span></td></tr> | ||
[[Category: Park | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TET55_UNKP TET55_UNKP] An FAD-requiring monooxygenase active on tetracycline antibiotic and some of its derivatives, which leads to their inactivation (PubMed:26097034). Expression in E.coli confers high resistance to oxytetracycline, slightly less resistance to tetracycline, moderate resistance to minocycline but no resistance to tigecycline. Degrades tetracycline and oxytetracycline; the reaction requires NADPH (PubMed:26097034). Degrades and confers resistance to chlortetracycline (PubMed:28481346).<ref>PMID:26097034</ref> <ref>PMID:28481346</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Uncultured bacterium]] | |||
[[Category: Park J]] | |||
[[Category: Tolia NH]] | |||
Latest revision as of 14:23, 6 March 2024
Crystal structure of tetracycline destructase Tet(55)
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