5uz0: Difference between revisions

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'''Unreleased structure'''


The entry 5uz0 is ON HOLD
==Crystal structure of AICARFT bound to an antifolate==
<StructureSection load='5uz0' size='340' side='right'caption='[[5uz0]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5uz0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UZ0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8US:N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide'>8US</scene>, <scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uz0 OCA], [https://pdbe.org/5uz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uz0 RCSB], [https://www.ebi.ac.uk/pdbsum/5uz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uz0 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PUR9_HUMAN PUR9_HUMAN] Defects in ATIC are the cause of AICAR transformylase/IMP cyclohydrolase deficiency (AICAR) [MIM:[https://omim.org/entry/608688 608688]. A neurologically devastating inborn error of purine biosynthesis. Patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA-ribotide and its derivatives in erythrocytes and fibroblasts. AICAR causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness.<ref>PMID:14966129</ref> <ref>PMID:15114530</ref>
== Function ==
[https://www.uniprot.org/uniprot/PUR9_HUMAN PUR9_HUMAN] Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.<ref>PMID:14966129</ref>


Authors: Shane Atwell, Yong Wang, Kevin R. Fales, David Clawson, Jing Wang
==See Also==
 
*[[Bifunctional purine biosynthesis protein PURH|Bifunctional purine biosynthesis protein PURH]]
Description: Crystal structure of AICARFT bound to an antifolate.
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Shane Atwell, Yong Wang, Kevin R. Fales, David Clawson, Jing Wang]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Atwell S]]
[[Category: Clawson D]]
[[Category: Fales KR]]
[[Category: Wang J]]
[[Category: Wang Y]]
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