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==Crystal structure of the S.pombe Smc5/6 hinge domain==
==Crystal structure of the S.pombe Smc5/6 hinge domain==
<StructureSection load='5mg8' size='340' side='right' caption='[[5mg8]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='5mg8' size='340' side='right'caption='[[5mg8]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5mg8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MG8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5mg8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MG8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mg8 OCA], [http://pdbe.org/5mg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mg8 RCSB], [http://www.ebi.ac.uk/pdbsum/5mg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mg8 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mg8 OCA], [https://pdbe.org/5mg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mg8 RCSB], [https://www.ebi.ac.uk/pdbsum/5mg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mg8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SMC5_SCHPO SMC5_SCHPO]] Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. [[http://www.uniprot.org/uniprot/SMC6_SCHPO SMC6_SCHPO]] Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis.<ref>PMID:10473635</ref> 
[https://www.uniprot.org/uniprot/SMC5_SCHPO SMC5_SCHPO] Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Alt, A]]
[[Category: Large Structures]]
[[Category: Oliver, A W]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Pearl, L H]]
[[Category: Alt A]]
[[Category: Hinge domain]]
[[Category: Oliver AW]]
[[Category: Recombination]]
[[Category: Pearl LH]]
[[Category: Smc]]
[[Category: Smc5]]
[[Category: Smc5/6]]
[[Category: Smc6]]
[[Category: Structural maintenance of chromosome]]
Retrieved from "https://proteopedia.org/5mg8"