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==Crystal structure of SopA-Trim56 complex==
==Crystal structure of SopA-Trim56 complex==
<StructureSection load='5jw7' size='340' side='right' caption='[[5jw7]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
<StructureSection load='5jw7' size='340' side='right'caption='[[5jw7]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5jw7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JW7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5jw7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JW7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.849&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw7 OCA], [http://pdbe.org/5jw7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jw7 RCSB], [http://www.ebi.ac.uk/pdbsum/5jw7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw7 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw7 OCA], [https://pdbe.org/5jw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jw7 RCSB], [https://www.ebi.ac.uk/pdbsum/5jw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SOPA_SALTY SOPA_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Required for inducing polymorphonuclear leukocytes migration across the intestinal epithelium. Preferentially uses host UBE2D1 (UBCH5A), UBE2D2 (UBCH5B) and UBE2L3 (UBCH7) as E2 ubiquitin-conjugating enzymes.<ref>PMID:17076670</ref> <ref>PMID:18066077</ref> [[http://www.uniprot.org/uniprot/TRI56_HUMAN TRI56_HUMAN]] E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).[UniProtKB:Q80VI1]<ref>PMID:21289118</ref> <ref>PMID:22948160</ref> 
[https://www.uniprot.org/uniprot/SOPA_SALTY SOPA_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Required for inducing polymorphonuclear leukocytes migration across the intestinal epithelium. Preferentially uses host UBE2D1 (UBCH5A), UBE2D2 (UBCH5B) and UBE2L3 (UBCH7) as E2 ubiquitin-conjugating enzymes.<ref>PMID:17076670</ref> <ref>PMID:18066077</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5jw7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jw7" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bhogaraju, S]]
[[Category: Homo sapiens]]
[[Category: Dikic, I]]
[[Category: Large Structures]]
[[Category: Bacterial effector]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Ligase]]
[[Category: Bhogaraju S]]
[[Category: Sopa]]
[[Category: Dikic I]]
[[Category: Trim56]]
[[Category: Ubiquitination]]
Retrieved from "https://proteopedia.org/5jw7"