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New page: ==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis In the presence of G36== <StructureSection load='5upv' size='340' si...
 
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==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis In the presence of G36==
==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis In the presence of G36==
<StructureSection load='5upv' size='340' side='right' caption='[[5upv]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
<StructureSection load='5upv' size='340' side='right'caption='[[5upv]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5upv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UPV FirstGlance]. <br>
<table><tr><td colspan='2'>[[5upv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UPV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8KV:N-{(1S)-1-[3-METHOXY-4-(1,3-OXAZOL-5-YL)PHENYL]ETHYL}-N-PHENYLUREA'>8KV</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zqm|4zqm]], [[4zqn|4zqn]], [[4zqo|4zqo]], [[4zqp|4zqp]], [[4zqr|4zqr]], [[5upu|5upu]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8KV:N-{(1S)-1-[3-METHOXY-4-(1,3-OXAZOL-5-YL)PHENYL]ETHYL}-N-PHENYLUREA'>8KV</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5upv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5upv OCA], [https://pdbe.org/5upv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5upv RCSB], [https://www.ebi.ac.uk/pdbsum/5upv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5upv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5upv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5upv OCA], [http://pdbe.org/5upv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5upv RCSB], [http://www.ebi.ac.uk/pdbsum/5upv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5upv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IMDH_MYCTU IMDH_MYCTU]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]  
[https://www.uniprot.org/uniprot/IMDH_MYCTU IMDH_MYCTU] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
 
==See Also==
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: IMP dehydrogenase]]
[[Category: Large Structures]]
[[Category: Anderson, W F]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Structural genomic]]
[[Category: Anderson WF]]
[[Category: Gu, M]]
[[Category: Gu M]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak A]]
[[Category: Kim, Y]]
[[Category: Kim Y]]
[[Category: Makowska-Grzyska, M]]
[[Category: Makowska-Grzyska M]]
[[Category: Maltseva, N]]
[[Category: Maltseva N]]
[[Category: Mulligan, R]]
[[Category: Mulligan R]]
[[Category: Csgid]]
[[Category: Delta cb]]
[[Category: Impdh]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
Retrieved from "https://proteopedia.org/5upv"