5upu: Difference between revisions
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==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the presence of TBK6== | ==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the presence of TBK6== | ||
<StructureSection load='5upu' size='340' side='right' caption='[[5upu]], [[Resolution|resolution]] 2.91Å' scene=''> | <StructureSection load='5upu' size='340' side='right'caption='[[5upu]], [[Resolution|resolution]] 2.91Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5upu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPU OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5upu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UPU FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6Q9:~{N}-(2~{H}-INDAZOL-6-YL)-3,5-DIMETHYL-1~{H}-PYRAZOLE-4-SULFONAMIDE'>6Q9</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.905Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6Q9:~{N}-(2~{H}-INDAZOL-6-YL)-3,5-DIMETHYL-1~{H}-PYRAZOLE-4-SULFONAMIDE'>6Q9</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5upu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5upu OCA], [https://pdbe.org/5upu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5upu RCSB], [https://www.ebi.ac.uk/pdbsum/5upu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5upu ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/IMDH_MYCTU IMDH_MYCTU] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] | ||
==See Also== | |||
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: | [[Category: Anderson WF]] | ||
[[Category: Gu | [[Category: Gu M]] | ||
[[Category: Joachimiak | [[Category: Joachimiak A]] | ||
[[Category: Kim | [[Category: Kim Y]] | ||
[[Category: Makowska-Grzyska | [[Category: Makowska-Grzyska M]] | ||
[[Category: Maltseva | [[Category: Maltseva N]] | ||
[[Category: Mulligan | [[Category: Mulligan R]] | ||
[[Category: Sacchettini | [[Category: Sacchettini J]] | ||
Latest revision as of 13:32, 4 October 2023
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the presence of TBK6
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