3zp5: Difference between revisions
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==Crystal structure of the DNA binding ETS domain of the human protein FEV in complex with DNA== | ==Crystal structure of the DNA binding ETS domain of the human protein FEV in complex with DNA== | ||
<StructureSection load='3zp5' size='340' side='right' caption='[[3zp5]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3zp5' size='340' side='right'caption='[[3zp5]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3zp5]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3zp5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZP5 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp5 OCA], [https://pdbe.org/3zp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zp5 RCSB], [https://www.ebi.ac.uk/pdbsum/3zp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zp5 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry. A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN] Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.<ref>PMID:12761502</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Allerston | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Synthetic construct]] | ||
[[Category: Burgess-Brown | [[Category: Allerston CK]] | ||
[[Category: Cooper | [[Category: Arrowsmith CH]] | ||
[[Category: Burgess-Brown N]] | |||
[[Category: Edwards | [[Category: Cooper CDO]] | ||
[[Category: Gileadi | [[Category: Edwards A]] | ||
[[Category: Krojer | [[Category: Gileadi O]] | ||
[[Category: Newman | [[Category: Krojer T]] | ||
[[Category: Shrestha | [[Category: Newman JA]] | ||
[[Category: Vollmar | [[Category: Shrestha L]] | ||
[[Category: | [[Category: Vollmar M]] | ||
[[Category: Von Delft F]] | |||
