5ubb: Difference between revisions
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==Crystal structure of human alpha N-terminal protein methyltransferase 1B== | |||
<StructureSection load='5ubb' size='340' side='right'caption='[[5ubb]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ubb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UBB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ubb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubb OCA], [https://pdbe.org/5ubb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ubb RCSB], [https://www.ebi.ac.uk/pdbsum/5ubb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubb ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/NTM1B_HUMAN NTM1B_HUMAN] Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation.<ref>PMID:24090352</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Tempel | </StructureSection> | ||
[[Category: Zhu | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Dong A]] | |||
[[Category: Dong C]] | |||
[[Category: Edwards AM]] | |||
[[Category: Min J]] | |||
[[Category: Tempel W]] | |||
[[Category: Zhu L]] | |||
Latest revision as of 14:26, 6 March 2024
Crystal structure of human alpha N-terminal protein methyltransferase 1B
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