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==Plexin A2 extracellular segment domains 4-5 (PSI2-IPT2), resolution 1.36 Angstrom==
==Plexin A2 extracellular segment domains 4-5 (PSI2-IPT2), resolution 1.36 Angstrom==
<StructureSection load='5l74' size='340' side='right' caption='[[5l74]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
<StructureSection load='5l74' size='340' side='right'caption='[[5l74]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5l74]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L74 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5l74]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L74 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l74 OCA], [http://pdbe.org/5l74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l74 RCSB], [http://www.ebi.ac.uk/pdbsum/5l74 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l74 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l74 OCA], [https://pdbe.org/5l74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l74 RCSB], [https://www.ebi.ac.uk/pdbsum/5l74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l74 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PLXA2_MOUSE PLXA2_MOUSE]] Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref> <ref>PMID:20877282</ref>
[https://www.uniprot.org/uniprot/PLXA2_MOUSE PLXA2_MOUSE] Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref> <ref>PMID:20877282</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5l74" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5l74" style="background-color:#fffaf0;"></div>
==See Also==
*[[Plexin 3D structures|Plexin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Coles, C H]]
[[Category: Large Structures]]
[[Category: Gilbert, R J.C]]
[[Category: Mus musculus]]
[[Category: Janssen, B J.C]]
[[Category: Coles CH]]
[[Category: Jones, E Y]]
[[Category: Gilbert RJC]]
[[Category: Kaufmann, R]]
[[Category: Janssen BJC]]
[[Category: Kong, Y]]
[[Category: Jones EY]]
[[Category: Malinauskas, T]]
[[Category: Kaufmann R]]
[[Category: Ni, T]]
[[Category: Kong Y]]
[[Category: Padilla-Parra, S]]
[[Category: Malinauskas T]]
[[Category: Pasterkamp, R J]]
[[Category: Ni T]]
[[Category: Vangoor, V R]]
[[Category: Padilla-Parra S]]
[[Category: Axon guidance]]
[[Category: Pasterkamp RJ]]
[[Category: Psi-ipt domain]]
[[Category: Vangoor VR]]
[[Category: Receptor]]
[[Category: Signaling protein]]
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