5jv1: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:


==Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-066==
==Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-066==
<StructureSection load='5jv1' size='340' side='right' caption='[[5jv1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5jv1' size='340' side='right'caption='[[5jv1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5jv1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JV1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5jv1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JV1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YL6:[(1R)-1-{[6-(3-CHLORO-4-METHYLPHENYL)THIENO[2,3-D]PYRIMIDIN-4-YL]AMINO}-2-(3-FLUOROPHENYL)ETHYL]PHOSPHONIC+ACID'>YL6</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jv2|5jv2]], [[5jv0|5jv0]], [[5juz|5juz]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YL6:[(1R)-1-{[6-(3-CHLORO-4-METHYLPHENYL)THIENO[2,3-D]PYRIMIDIN-4-YL]AMINO}-2-(3-FLUOROPHENYL)ETHYL]PHOSPHONIC+ACID'>YL6</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jv1 OCA], [http://pdbe.org/5jv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jv1 RCSB], [http://www.ebi.ac.uk/pdbsum/5jv1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jv1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jv1 OCA], [https://pdbe.org/5jv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jv1 RCSB], [https://www.ebi.ac.uk/pdbsum/5jv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jv1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.  
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 5jv1" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jv1" style="background-color:#fffaf0;"></div>
==See Also==
*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Berghuis, A M]]
[[Category: Homo sapiens]]
[[Category: Leung, C Y]]
[[Category: Large Structures]]
[[Category: Park, J]]
[[Category: Berghuis AM]]
[[Category: Tsantrizos, Y S]]
[[Category: Leung CY]]
[[Category: Transferase]]
[[Category: Park J]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Tsantrizos YS]]
Retrieved from "https://proteopedia.org/5jv1"