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[[Image:1tpy.jpg|left|200px]]


{{Structure
==Structure of the cyclopropane synthase MmaA2 from Mycobacterium tuberculosis==
|PDB= 1tpy |SIZE=350|CAPTION= <scene name='initialview01'>1tpy</scene>, resolution 2.2&Aring;
<StructureSection load='1tpy' size='340' side='right'caption='[[1tpy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=16A:CETYL-TRIMETHYL-AMMONIUM'>16A</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
<table><tr><td colspan='2'>[[1tpy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TPY FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclopropane-fatty-acyl-phospholipid_synthase Cyclopropane-fatty-acyl-phospholipid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.79 2.1.1.79] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
|GENE= mmaA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16A:CETYL-TRIMETHYL-AMMONIUM'>16A</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tpy OCA], [https://pdbe.org/1tpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tpy RCSB], [https://www.ebi.ac.uk/pdbsum/1tpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tpy ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tpy OCA], [http://www.ebi.ac.uk/pdbsum/1tpy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tpy RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/MMAA2_MYCTU MMAA2_MYCTU] Catalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. MmaA2 also catalyzes the biosynthesis of the cis-cyclopropanated methoxymycolates. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.<ref>PMID:12502719</ref> <ref>PMID:20472794</ref>
 
== Evolutionary Conservation ==
'''Structure of the cyclopropane synthase MmaA2 from Mycobacterium tuberculosis'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tp/1tpy_consurf.spt"</scriptWhenChecked>
1TPY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPY OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Cyclopropane-fatty-acyl-phospholipid synthase]]
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tpy ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Sacchettini JC]]
[[Category: Sacchettini, J C.]]
[[Category: Smith CV]]
[[Category: Smith, C V.]]
[[Category: cyclopropane synthase]]
[[Category: methyltransferase]]
[[Category: mycolic acid]]
[[Category: sam-dependent]]
[[Category: tuberculosis]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:59:30 2008''

Latest revision as of 06:32, 23 August 2023

Structure of the cyclopropane synthase MmaA2 from Mycobacterium tuberculosis

1tpy, resolution 2.20Å

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