1tq3: Difference between revisions

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[[Image:1tq3.gif|left|200px]]


{{Structure
==Higher resolution crystal structure of the third PDZ domain of post synaptic PSD-95 protein==
|PDB= 1tq3 |SIZE=350|CAPTION= <scene name='initialview01'>1tq3</scene>, resolution 1.89&Aring;
<StructureSection load='1tq3' size='340' side='right'caption='[[1tq3]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1tq3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQ3 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
|GENE= DLG4, DLGH4, PSD95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq3 OCA], [https://pdbe.org/1tq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tq3 RCSB], [https://www.ebi.ac.uk/pdbsum/1tq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tq3 ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tq3 OCA], [http://www.ebi.ac.uk/pdbsum/1tq3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tq3 RCSB]</span>
[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''Higher resolution crystal structure of the third PDZ domain of post synaptic PSD-95 protein'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tq3_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
1TQ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQ3 OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tq3 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Kovari L]]
[[Category: Kovari, L.]]
[[Category: Saro D]]
[[Category: Saro, D.]]
[[Category: Spaller M]]
[[Category: Spaller, M.]]
[[Category: Vickrey J]]
[[Category: Vickrey, J.]]
[[Category: Wawrzak Z]]
[[Category: Wawrzak, Z.]]
[[Category: peptide binding protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:59:36 2008''
Retrieved from "https://proteopedia.org/1tq3"