1tqi: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(11 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1tqi.gif|left|200px]]


{{Structure
==Crystal Structure of A. Fulgidus Rio2 Serine Protein Kinase==
|PDB= 1tqi |SIZE=350|CAPTION= <scene name='initialview01'>1tqi</scene>, resolution 2.00&Aring;
<StructureSection load='1tqi' size='340' side='right'caption='[[1tqi]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
<table><tr><td colspan='2'>[[1tqi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQI FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE= RIO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 Archaeoglobus fulgidus DSM 4304])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqi OCA], [https://pdbe.org/1tqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tqi RCSB], [https://www.ebi.ac.uk/pdbsum/1tqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tqi ProSAT]</span></td></tr>
|RELATEDENTRY=[[1tqm|1TQM]], [[1tqp|1TQP]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqi OCA], [http://www.ebi.ac.uk/pdbsum/1tqi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tqi RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/RIO2_ARCFU RIO2_ARCFU]
 
== Evolutionary Conservation ==
'''Crystal Structure of A. Fulgidus Rio2 Serine Protein Kinase'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==Overview==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tqi_consurf.spt"</scriptWhenChecked>
The RIO family of atypical serine/threonine kinases contains two subfamilies, Rio1 and Rio2, highly conserved from archaea to man. Both RIO proteins from Saccharomyces cerevisiae catalyze serine phosphorylation in vitro, and the presence of conserved catalytic residues is required for cell viability. The activity of Rio2 is necessary for rRNA cleavage in 40S ribosomal subunit maturation. We solved the X-ray crystal structure of Archaeoglobus fulgidus Rio2, with and without bound nucleotides, at 2.0 A resolution. The C-terminal RIO domain is indeed structurally homologous to protein kinases, although it differs from known serine kinases in ATP binding and lacks the regions important for substrate binding. Unexpectedly, the N-terminal Rio2-specific domain contains a winged helix fold, seen primarily in DNA-binding proteins. These discoveries have implications in determining the target and function of RIO proteins and define a distinct new family of protein kinases.
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1TQI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_dsm_4304 Archaeoglobus fulgidus dsm 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQI OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tqi ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases., LaRonde-LeBlanc N, Wlodawer A, Structure. 2004 Sep;12(9):1585-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15341724 15341724]
</StructureSection>
[[Category: Archaeoglobus fulgidus dsm 4304]]
[[Category: Archaeoglobus fulgidus DSM 4304]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: LaRonde-LeBlanc, N.]]
[[Category: LaRonde-LeBlanc N]]
[[Category: Wlodawer, A.]]
[[Category: Wlodawer A]]
[[Category: serine kinase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:59:41 2008''

Latest revision as of 08:41, 14 February 2024

Crystal Structure of A. Fulgidus Rio2 Serine Protein Kinase

1tqi, resolution 2.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1tqi&oldid=4055660"