5q04: Difference between revisions

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~~'''Unreleased structure'''~~

~~The~~ entry ~~5q04~~ is ~~ON HOLD~~

==Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromo-5-chlorothiophen-2-yl)sulfonyl-3-(5-bromo-1,3-thiazol-2-yl)urea==

== Structural highlights ==

<table><tr><td colspan='2'>[[5q04]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Q04 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=5Q04 FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.502Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=95P:4-bromo-N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-chlorothiophene-2-sulfonamide'>95P</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=5q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5q04 OCA], [https://pdbe.org/5q04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5q04 RCSB], [https://www.ebi.ac.uk/pdbsum/5q04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5q04 ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>

== Function ==

[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]

~~Authors: Yang, Huanwang~~

==See Also==

*[[Fructose-1%2C6-bisphosphatase 3D structures|Fructose-1%2C6-bisphosphatase 3D structures]]

~~Description: Ligand binding to FRUCTOSE~~-1,6-~~BISPHOSPHATASE~~

== References ==

[[Category: ~~Unreleased~~ Structures]]

[[Category: Yang~~, Huanwang~~]]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Alker A]]

[[Category: Banner D]]

[[Category: Benz J]]

[[Category: Burley SK]]

[[Category: Joseph C]]

[[Category: Kuhn B]]

[[Category: Rudolph MG]]

[[Category: Ruf A]]

[[Category: Shao C]]

[[Category: Tetaz T]]

[[Category: Yang H]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5q04 is ON HOLD
+==Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromo-5-chlorothiophen-2-yl)sulfonyl-3-(5-bromo-1,3-thiazol-2-yl)urea==
+<StructureSection load='5q04' size='340' side='right'caption='[[5q04]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5q04]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Q04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Q04 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.502&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=95P:4-bromo-N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-chlorothiophene-2-sulfonamide'>95P</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5q04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5q04 OCA], [https://pdbe.org/5q04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5q04 RCSB], [https://www.ebi.ac.uk/pdbsum/5q04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5q04 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]
-Authors: Yang, Huanwang
+==See Also==
+*[[Fructose-1%2C6-bisphosphatase 3D structures|Fructose-1%2C6-bisphosphatase 3D structures]]
-Description: Ligand binding to FRUCTOSE-1,6-BISPHOSPHATASE
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Yang, Huanwang]]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Alker A]]
+[[Category: Banner D]]
+[[Category: Benz J]]
+[[Category: Burley SK]]
+[[Category: Joseph C]]
+[[Category: Kuhn B]]
+[[Category: Rudolph MG]]
+[[Category: Ruf A]]
+[[Category: Shao C]]
+[[Category: Tetaz T]]
+[[Category: Yang H]]