5v6z: Difference between revisions

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'''Unreleased structure'''


The entry 5v6z is ON HOLD
==Crystal structure of human caspase-7 soaked with allosteric inhibitor 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}benzoic acid==
<StructureSection load='5v6z' size='340' side='right'caption='[[5v6z]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5v6z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V6Z FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8YJ:2-[2-(4-chlorophenyl)-2-oxidanylidene-ethyl]sulfanylbenzoic+acid'>8YJ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v6z OCA], [https://pdbe.org/5v6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v6z RCSB], [https://www.ebi.ac.uk/pdbsum/5v6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v6z ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.


Authors:  
==See Also==
 
*[[Caspase 3D structures|Caspase 3D structures]]
Description:  
__TOC__
[[Category: Unreleased Structures]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gakhar L]]
[[Category: Spies MA]]
[[Category: Vance NR]]
Retrieved from "https://proteopedia.org/5v6z"