5nkp: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,884 edits
m Protected "5nkp" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,884 edits
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 5nkp is ON HOLD
==Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide==
<StructureSection load='5nkp' size='340' side='right'caption='[[5nkp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5nkp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NKP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nkp OCA], [https://pdbe.org/5nkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nkp RCSB], [https://www.ebi.ac.uk/pdbsum/5nkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nkp ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KLHL3_HUMAN KLHL3_HUMAN] Pseudohypoaldosteronism type 2D. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/KLHL3_HUMAN KLHL3_HUMAN] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation.<ref>PMID:14528312</ref> <ref>PMID:23387299</ref> <ref>PMID:23453970</ref> <ref>PMID:23665031</ref> <ref>PMID:23576762</ref> <ref>PMID:22406640</ref>


Authors: Chen, Z., Sorrell, F.J., Pinkas, D.M., Williams, E., Mathea, S., Goubin, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
==See Also==
 
*[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]]
Description: Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Bullock, A]]
__TOC__
[[Category: Goubin, S]]
</StructureSection>
[[Category: Mathea, S]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.H]]
[[Category: Large Structures]]
[[Category: Williams, E]]
[[Category: Arrowsmith CH]]
[[Category: Von Delft, F]]
[[Category: Bountra C]]
[[Category: Pinkas, D.M]]
[[Category: Bullock A]]
[[Category: Edwards, A.M]]
[[Category: Burgess-Brown N]]
[[Category: Chen, Z]]
[[Category: Chen Z]]
[[Category: Bountra, C]]
[[Category: Edwards AM]]
[[Category: Sorrell, F.J]]
[[Category: Goubin S]]
[[Category: Mathea S]]
[[Category: Pinkas DM]]
[[Category: Sorrell FJ]]
[[Category: Williams E]]
[[Category: Von Delft F]]
Retrieved from "https://proteopedia.org/5nkp"