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==MORF double PHD finger (DPF) in complex with histone H3K14bu==
==MORF double PHD finger (DPF) in complex with histone H3K14bu==
<StructureSection load='5u2j' size='340' side='right' caption='[[5u2j]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='5u2j' size='340' side='right'caption='[[5u2j]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5u2j]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U2J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U2J FirstGlance]. <br>
<table><tr><td colspan='2'>[[5u2j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U2J FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTK:N~6~-BUTANOYL-L-LYSINE'>BTK</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTK:N~6~-BUTANOYL-L-LYSINE'>BTK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u2j OCA], [https://pdbe.org/5u2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u2j RCSB], [https://www.ebi.ac.uk/pdbsum/5u2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u2j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u2j OCA], [http://pdbe.org/5u2j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u2j RCSB], [http://www.ebi.ac.uk/pdbsum/5u2j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u2j ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/KAT6B_HUMAN KAT6B_HUMAN]] Genitopatellar syndrome;Noonan syndrome;Blepharophimosis-intellectual disability syndrome, SBBYS type. A chromosomal aberration involving KAT6B may be a cause acute myeloid leukemias. Translocation t(10;16)(q22;p13) with CREBBP.<ref>PMID:11157802</ref>  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KAT6B_HUMAN KAT6B_HUMAN]] Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.<ref>PMID:10497217</ref> <ref>PMID:11965546</ref> <ref>PMID:16387653</ref> 
[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5u2j" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5u2j" style="background-color:#fffaf0;"></div>
==See Also==
*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Histone acetyltransferase]]
[[Category: Homo sapiens]]
[[Category: Andrews, F H]]
[[Category: Large Structures]]
[[Category: Klein, B J]]
[[Category: Andrews FH]]
[[Category: Kutateladze, T G]]
[[Category: Klein BJ]]
[[Category: Acyllysine]]
[[Category: Kutateladze TG]]
[[Category: Epigenetic]]
[[Category: Hydrolase]]
[[Category: Transcription]]

Latest revision as of 09:41, 2 April 2025

MORF double PHD finger (DPF) in complex with histone H3K14bu

5u2j, resolution 1.60Å

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