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==Structure of human TSLP in complex with TSLPR and IL-7Ralpha==
==Structure of human TSLP in complex with TSLPR and IL-7Ralpha==
<StructureSection load='5j11' size='340' side='right' caption='[[5j11]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
<StructureSection load='5j11' size='340' side='right'caption='[[5j11]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5j11]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J11 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5j11]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J11 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j11 OCA], [http://pdbe.org/5j11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j11 RCSB], [http://www.ebi.ac.uk/pdbsum/5j11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j11 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j11 OCA], [https://pdbe.org/5j11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j11 RCSB], [https://www.ebi.ac.uk/pdbsum/5j11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j11 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TSLP_HUMAN TSLP_HUMAN]] Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.<ref>PMID:11418668</ref> <ref>PMID:11480573</ref> <ref>PMID:17242164</ref>  Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.<ref>PMID:24850429</ref> [[http://www.uniprot.org/uniprot/CRLF2_HUMAN CRLF2_HUMAN]] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.<ref>PMID:11418668</ref> 
[https://www.uniprot.org/uniprot/TSLP_HUMAN TSLP_HUMAN] Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.<ref>PMID:11418668</ref> <ref>PMID:11480573</ref> <ref>PMID:17242164</ref>  Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.<ref>PMID:24850429</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5j11" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5j11" style="background-color:#fffaf0;"></div>
==See Also==
*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Savvides, S N]]
[[Category: Homo sapiens]]
[[Category: Verstraete, K]]
[[Category: Large Structures]]
[[Category: Cytokine inflammation tslp signaling complex]]
[[Category: Savvides SN]]
[[Category: Signaling protein]]
[[Category: Verstraete K]]
Retrieved from "https://proteopedia.org/5j11"