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==Structure of E. coli MCE protein MlaD, core MCE domain==
==Structure of E. coli MCE protein MlaD, core MCE domain==
<StructureSection load='5uw8' size='340' side='right' caption='[[5uw8]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='5uw8' size='340' side='right'caption='[[5uw8]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5uw8]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UW8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5uw8]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UW8 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uvn|5uvn]], [[5uw2|5uw2]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uw8 OCA], [http://pdbe.org/5uw8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uw8 RCSB], [http://www.ebi.ac.uk/pdbsum/5uw8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uw8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uw8 OCA], [https://pdbe.org/5uw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uw8 RCSB], [https://www.ebi.ac.uk/pdbsum/5uw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uw8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MLAD_ECO57 MLAD_ECO57]] Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane.[UniProtKB:P64604]  
[https://www.uniprot.org/uniprot/MLAD_ECO57 MLAD_ECO57] Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane.[UniProtKB:P64604]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
How phospholipids are trafficked between the bacterial inner and outer membranes through the hydrophilic space of the periplasm is not known. We report that members of the mammalian cell entry (MCE) protein family form hexameric assemblies with a central channel capable of mediating lipid transport. The E. coli MCE protein, MlaD, forms a ring associated with an ABC transporter complex in the inner membrane. A soluble lipid-binding protein, MlaC, ferries lipids between MlaD and an outer membrane protein complex. In contrast, EM structures of two other E. coli MCE proteins show that YebT forms an elongated tube consisting of seven stacked MCE rings, and PqiB adopts a syringe-like architecture. Both YebT and PqiB create channels of sufficient length to span the periplasmic space. This work reveals diverse architectures of highly conserved protein-based channels implicated in the transport of lipids between the membranes of bacteria and some eukaryotic organelles.
 
Architectures of Lipid Transport Systems for the Bacterial Outer Membrane.,Ekiert DC, Bhabha G, Isom GL, Greenan G, Ovchinnikov S, Henderson IR, Cox JS, Vale RD Cell. 2017 Apr 6;169(2):273-285.e17. doi: 10.1016/j.cell.2017.03.019. PMID:28388411<ref>PMID:28388411</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5uw8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bhabha, G]]
[[Category: Escherichia coli O157:H7]]
[[Category: Ekiert, D C]]
[[Category: Large Structures]]
[[Category: Bacterial lipid transport]]
[[Category: Bhabha G]]
[[Category: Mce protein]]
[[Category: Ekiert DC]]
[[Category: Transport protein]]

Latest revision as of 14:29, 6 March 2024

Structure of E. coli MCE protein MlaD, core MCE domain

5uw8, resolution 2.15Å

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